Cumartesi, Ekim 1Gebze Enzyme Recognition Center


Lacin, K., Caloglu, B., Binay, B. 2023 “Anaerobic digestion methods for the production of fuels”, Bioenergy Engineering, Elsevier, Basımda.

Inam A., Taymaz E.R., Uslu M.E., Binay B., Deniz I. 2021 “Volumetric Mass Transfer Coefficient Measurement in a Stirred Tank Reactor”. Bioreactors in Stem Cell Biology. Methods in Molecular Biology, Springer, 2436.

-Ergün, B. G., Berrious, J., Binay, B., Fickers, P. 2021. “Recombinant protein production in Pichia pastoris: From transcriptionally redesigned strains to bioprocess optimization and metabolic modelling”. FEMS Yeast Research, doi:10.1093/femsyr/foab057

– Karataş, E., Tulek, A., Yıldırım, D., Tamturk, F., Binay, B., 2021 “Immobilization of Sporothrix schenckii 1099-18 exo-polygalacturonase in magnetic mesoporous silica yolk-shell spheres: Highly reusable biocatalysts for apple juice clarification”, Food Bioscience, 43, 101324

Binay, B., 2021 “Editorial – II. International Enzyme and Bioprocess Days”, Biocatalysis and Biotransformation, 39(4), 241

 Alpdağtaş, S., Turunen, O., Valjakka, J., Binay, B., 2021 ” The challenges of using NAD+-dependent formate dehydrogenases for CO2 conversion”, Critical Reviews in Biotechnology, 42(6), 953-972

Unlu, A., Duman, Z.E., Caloglu, B., Binay, B., 2021  “Enzymes for Efficient CO2 Conversion” The Protein Journal, 40(4), 489-503

Binay, B., 2021 “Introduction to International Enzyme and Bioprocess Days (EBDays)” The Protein Journal, 40(3), 341

Ar, E., Demiroğlu, A., Yılmaz, M.S., Yılmazer,B. Sibel Aslan, E., Binay, B., 2021. “Enhancing recombinant Chaetomium thermophilium Formate Dehydrogenase Expression with CRISPR Technology” The Protein Journal, 40(4), 504-511

Duman, Z.E., Binay, B., 2021 ” Production of Industrial Enzymes via Pichia pastoris as a Cell Factory in Bioreactor: Current Status and Future Aspects ” The Protein Journal, 40(3), 367-376

– Alkan-Tas, B.,  Durmus-Sayar, A.,  Duman, Z.E.,  Sevinis-Ozbulut, B.E. , Unlu, A., Binay, B., Unal, S., Unal, H. 2021 ” Antibacterial hybrid coatings from halloysite-immobilized lysostaphin and waterborne polyurethanes ” Progress in Organic Coatings, 156 106248

Tülek, A., Yildirim, D., Aydın, D., Binay, B. 2021. ” Highly-stable Madurella mycetomatis laccase immobilized in silica-coated ZIF-8 nanocomposites for environmentally friendly cotton bleaching process” Colloids and Surfaces B:  Biointerfaces, 202,  111672

Hebal, H., Boucherba, N., Binay, B., Turunen, O. 2021. ” Activity and stability of hyperthermostable cellulases and xylanases in organic liquids”Biocatalysis and Biotransformation,  39(4), 242-259

Duman-Özdamar, Z.E., Ünlü, A., Ünal H., Woodley, J.M., Binay, B. 2021. “High-Yield Production of Active Recombinant S. simulans Lysostaphin Expressed in E. coli in a Laboratory Bioreactor” Protein Expression and Purification, 177, 105753.

Karataş, E., Tülek, A., Çakar, M. M., Tamtürk, F., Aktaş, F., Binay, B. 2021. “From secretion in Pichia Pastoris to application in apple juice processing: Exopolygalacturonase from Sporothrix schenckii 1099-18″ Protein&Peptide Letters, 28(7), 817-830

Yılmazer B., Isupova M.N., De Rose S.A., Bulut H., Benninghoff J.C., Binay B., Littlechild J.A. 2020. “Structural insights into the NAD+-dependent formate dehydrogenase mechanism revealed from the NADH complex and the formate NAD+ ternary complex of the Chaetomium thermophilum enzyme” Structural Biology, 212(3),107657 .

Tülek, A., Karataş, E., Çakar, M. M., Aydın, D., Yılmazcan, Ö, Binay, B. 2020. “Optimisation of the Production and Bleaching Process for a New Laccase from Madurella mycetomatis, Expressed in Pichia pastoris: from Secretion to Yielding Prominent Performance” Molecular Biotechnology, 63(1), 24-39.

Bulut, H., Valjakka, J., Yuksel, B., Yilmazer, B., Turunen, O., Binay, B. 2020. ”Effect of Metal Ions on the Activity of Ten NAD+-Dependent Formate Dehydrogenases” The Protein Journal, 39(5), 519-530.

Bulut, H., Yuksel, B., Gul, M., Eren, M., Karatas, E., Kara, N., Yilmazer, B., Kocyigit, A., Labrou, N. E., Binay, B. 2020. “Conserved Amino acid Residues that Affect Structural Stability of Candida boidinii Formate Dehydrogenase” Applied Biochem and Biotech, 193(2),363-376.

Çakar, M.M., Ruupunen, J., Mangas-Sanchez, J., Birmingham, W.R., Yildirim, D., Turunen, O., Turner, N.J., Valjakka, J., Binay, B. 2020. “Engineered Formate Dehydrogenase from Chaetomium thermophilum, a Promising Enzymatic Solution for Biotechnical CO2 Fixation” Biotechnology Letters, 42(11), 2251-2262.

Babavatan, E.Ö., Yildirim, D., Peksel, A., Binay, B. 2020. “Immobilization of Rhizomucor miehei lipase onto Montmorillonite K-10 and polyvinyl alcohol gel” Biocatalysis and Biotransformation, 38(4), 274-282.

Duman, Z.D., Duraksoy, B.B., Aktas, F., Woodley, J.M., Binay, B. 2020. “High-level heterologous expression of active Chaetomium thermophilum FDH in Pichia pastoris” Enzyme and Microbial Technology, 137, 109552.

Alpdağdaş, S., Binay, B. 2020. “NADP+ dependent formate dehydrogenase: A Review” Biocatalysis and Biotransformation,  39(4), 260-268

Koçdemir K., Şen F., Wadejo Y.A., Bilgici M.Ç., Bayram M., Selçuk İ., Yılmazer B., Çakar M.M., Aslan E.S., Binay B. 2020. “Investigation new positions for catalytic activity of Chaetomium thermophilum and Ceriporiopsis subvermispora Formate Dehydrogenases” Biocatalysis and Biotransformation, 39(4), 302-312

Binay, B., “EBAT 2018” 2019,Preparative Biochemistry and Biotechnology, doi: 10.1080/10826068.2019.1608704

Duman, Z.E., Unlu, A., Çakar, M.M., Unal, H. Binay, B. 2019. “Enhanced production of recombinant Staphylococcus simulans lysostaphin using medium engineering” Preperative Biochemistry and Biotechnology, 49(5), 521-28.

Esen, H., Alpdagtas, S., Cakar, M.M., Binay, B. 2019. “Tailoring of recombinant FDH: effect of histidine tag location on solubility and catalytic properties of Chateomium thermophilum formate dehydrogenase (CtFDH)”, Preperative Biochemistry and Biotechnology, 49(5), 529-34.

Pala, U., Yelmazer, B., Corbacioglu, M., Ruupunen, J., Valjakka, J., Turunen, O., Binay, B. 2018. “Functional effects of active site mutations in NAD+ -dependent formate dehydrogenases on transformation of hydrogen carbonate to formate”, Protein Engineering, Design and Selection, 31(9), 327-35.

Alpdağtaş, S., Çelik, A., Ertan, F., Binay, B. 2018. “DMSO tolerant NAD(P)H recycler enzyme from a pathogenic bacterium, Burkholderia dolosa PC543: effect of N-/C-terminal His Tag extension on protein solubility and activity”, Engineering in Life Sciences, 18(12), 893-903.

Alpdağtaş, S., Yücel, S., Kapkaç, H. A., Liu, S., Binay, B. 2018. “Discovery of an acidic, thermostable and highly NADP+ dependent formate dehydrogenase from Lactobacillus buchneri NRRL B-30929”, Biotechnology Letters, 40(7), 1135-47.

Çakar M. M., Mangas-Sanchez J., Birmingham W. R., Turner N. J., Binay B. 2018. “Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii”, Preparative Biochemistry and Biotechnology, 48(4), 327-334.

Altaş, N., Aşkın, A. S., Karataş, E., Chronopoulou, E., Labrou, N. E., Binay, B2017. “Heterologous production of extreme alkaline thermostable NAD+-dependent formate dehydrogenase with wide-range pH activity from Myceliophthora thermophila“, Process Biochemistry, 61, 110- 118.

Aslan, S.A., Valjakka, J., Ruupunen, J., Yildirim, D., Turner, N. J., Turunen, O., Binay, B. 2017. “Chaetomium thermophilum formate dehydrogenase has high activity in the reduction of hydrogen carbonate (HCO3-) to formate”, Protein Eng. Des. Select., 30, 47-55.

Alagöz, D., Çelik, A., Yildirim, D., Tükel, S.S., Binay B. 2016. “Covalent immobilization of Candida methylica formate dehydrogenase on short spacer arm aldehyde group containing supports”, Journal of Molecular Catalysis B: Enzymatic, 130, 40-47.

Yu, T., Wang, Y., Anbarasan, S., Telli, K., Aslan, A., Su, Z., Zhou, Y., Zhang, L., Iivonen, P., Havukainen, S., Mentunen, T., Hummel, M., Sixta, H., Binay, B., Turunen, O., Xiong, H. 2016. “Expression of a hyperthermostable Thermotoga maritima Xylanase XYN10B in Pichia pastoris and its stability and tolerance to ionic liquids”, Extremophiles, 20, 515-524.

Albuquerque, T., Rueda, N., dos Santos, J. C.S., Barbosa, O., Ortiz, C., Binay, B., Özdemir, E., Gonçalves, L. R. B., Fernandez-Lafuente, R. 2016. “Easy stabilization of interfacially activated lipases using heterofunctıonal divinylsulfone activated-octyl agarose beads. Modulation of the immobilized enzymes by altering their nanoenvironment”, Process Biochemistry, 160(51), 865-874.

Aslan, S.A., Birmingham, W.R., Karagüler, N.G., Turner, N.J., Binay, B. 2016. “Semirational design of Geobacillus stearothermophilus lactate dehydrogenase to access various chiral α-hydroxy acids”, Applied Biochem and Biotech., 179, 474-484.

Rowles, I., Groenendaal, B., Binay, B., Malone, K.J., Willies, S.C., Turner, N.J. 2016. “Engineering of Phenylalanine Ammonia Lyase from Rhodotorula graminis for the Synthesis of Unnatural L-Amino Acids”, Tetrahedron, 72, 7343-7347.

Alagoz, D., Binay, B., Yildirim, D., Celik, A., Tukel, S. S., 2016. “Improving of stability of formate dehydrogenase from Candida methylica by immobilization onto Eupergit C 250 L”, Biotekhnologiya, 32, 37-42.

Binay, B., Alagöz, D., Yildirim, Y., Çelik, A., Tükel, S.S. 2016. “Highly stable and reusable immobilized formate dehydrogenases: Promising biocatalysts in situ regeneration of NADH”, Beilstein Journal of Organic Chemistry, 12, 271-277.

Özgün, G., Karagüler, N.G., Turunen, O., Turner, N.J., Binay, B. 2015. “Characterization of a new acidic NAD+-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum“, Journal of Molecular Catalysis B: Enzymatic, 122, 212-217.

Binay, B., Sessions, R. B., Gül-Karagüler, N. 2013. “A double mutant of highly prufied Geobacillus stearothermophilus LDH recognizes mandelic acid as a subsbstrate”. Enzyme and Microbial Technology, 52, 393-399.

Binay, B., Shoemark, D.K., Sessions, R.B., Clarke, A.R., Karaguler, N.G. 2009. “Increasing the substrate specificity of the lactate dehydrogenase from Bacillus stearothermophilus by DNA shuffling”, Biochemical Engineering Journal, 48, 118-123.

Karagüler, N.G., Binay, B., Ordu, E.B., Clarke, A.R. 2007. “Protein engineering applications of industrially exploitable enzymes: Geobacillus stearothermophilus LDH and Candida methylica FDH”, Biochem. Soc. Trans., 35, 1610-1615.

Binay, B., Karagüler, N.G. 2007. “Attempting to remove the substrate inhibition of L-lactate dehydrogenase from Bacillus stearothermophilus by site-directed mutagenesis”, Appl. Biochem. Biotechnol., 141, 265-272.

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